2012
2ème semestre 2012
| 22 Novembre 14h |
José Pedro Lopes Garcia Computation Institute, University of Chicago LIeu:salle réunion de MIG jouy |
Titre: The ModelSEED pipeline for high-throughput generation of metabolic models and advances towards integrated metabolic regulatory models. Résumé : Genome-scale metabolic models have proven to be valuable for predicting organism phenotypes from genotypes. Yet efforts to develop new models are failing to keep pace with genome sequencing. To address this problem, we introduce the Model SEED, a web-based resource for high-throughput generation, optimization and analysis of genome-scale metabolic models. Advances in sequencing technology are resulting in the rapid emergence of large numbers of complete genome sequences. High throughput annotation and metabolic modeling of these genomes is now a reality. The high throughput reconstruction and analysis of genome-scale transcriptional regulatory networks represents the next frontier in microbial bioinformatics. The fruition of this next frontier will depend upon the integration of numerous data sources relating to mechanisms, components, and behavior of the transcriptional regulatory machinery, as well as the integration of the regulatory machinery into genome-scale cellular models. |
1er semestre 2012
| 21 Mars 14h |
Atsuko Yamaguchi DBCLS (ROIS Tokyo) LIeu:salle réunion de MIA jouy |
Titre: Integration of Multiple Life Science Databases Using RDF Résumé : From the late 1990s, the rapid growth of genome and post-genome projects have generated a massive amount of information, which is however scattered in various databases in various forms. Under this circumstance, we are developing an integrated environment that will enable us to access various life science databases seamlessly using semantic web technologies, such as RDF, ontologies, and so on. In this talk, I will introduce activities in DBCLS to accomplish the goal, which will include several public services and tool, and the BioHackathon, an annual meeting for intensive development and exchange of open-bio resources. |
| 20 Mars 14h |
Jin-Dong Kim DBCLS (ROIS Tokyo) LIeu:salle réunion de MIA jouy |
Titre: Ontology-based, public development and sharing of language resources. Résumé: Database Center for Life Science (DBCLS, Japan) is a research center whose mission is to develop public services and infrastructure for data sharing and integration. In its activities, language resources including ontologies, dictionaries and corpora with annotations are regarded as fundamental resources which are indispensible to glue pieces of data from various data sources. To promote the development and sharing of linguistic resources, we are developing frameworks and services with emphasis on "ontology-based, public" development and sharing. In the talk, I will talk about our efforts toward the direction, and intoduce new services and tools we are developing which will include OntoFinder, PubAnnotation, and BioQA. |