L'unité MIG et l'unité MIAJ ont fusionné au 1er janvier 2015. Elles constituent dorénavant la nouvelle unité MaIAGE dont le site internet est accessible via l'URL suivante : http://maiage.jouy.inra.fr.

Mahendra Mariadassou's Home Page


Presentation :

I work as a junior researcher at the INRA Jouy-en-Josas campus in the Mathématique, Informatique et Génome laboratory (MIG). I am mainly interested in evolutionary genomics with a special interest in robust phylogenetic inferrence, outlier detection in evolutionary studies (rogue taxa/influent sites), phylogenetic comparative methods (linking genotypes to phenotypes). I'm also interested in metagenomics, with a special interest in models for metagenome evolution (using adequate representation of a metagenome) and statistical modeling of biological networks (using mixture models).

Background :

* Junior Researcher at MIG-INRA since September 2010
* PhD in Statistics (2009): Laboratoire de mathématiques d'Orsay (Université Paris-Sud 11), Laboratoire MAP5 (Université Paris-Descartes) and Laboratory of Biometry and Bioinformatics (University of Tokyo).
* Alumni of École Normale Supérieure (ENS).
* More in the CV

Contact Information :

Email : mahendra.mariadassou[at]jouy.inra.fr
Phone : 01 34 65 29 00
Postal Mail: MIG-INRA (bât. 233) Domaine de Vilvert 78352 Jouy en Josas Cedex





  • S. Pichon, M. Mariadassou, E. Burcklen, J.W. Hottinger and D. Ebert. Coexisting Daphnia species in one aquatic environment have unique bacterial communities. Submitted to Environ. Microbiol.
  • P. Bastide, M. Mariadassou and S. Robin. Detection of adaptive shifts on phylogenies using shifted stochastic
      processes on a tree. In revision at JRSSB. arXiv:1508.00225
  • A. François, D. Grebert, M. Rhimi, M. Mariadassou, L. Naudon, S. Rabot, N. Meunier. Olfactory epithelium changes in germfree mice. Submitted to Scientific Reports
  • S.M. Deutsch, S. Parayre, R. Le Guellec, V. Chuat, V. Loux, M. Mariadassou, P. Nicolas, J. Jardin, V. Briard, C. Plé, B. Foligné, G. Jan, H. Falentin. Identification of proteins involved in anti-inflammatory properties of Propionibacterium freudenreichii by a multi-omics approach.

In peer-reviewed journals

  • J. Alard, V. Lehrter, M. Rhimi, I. Mangin, V. Peucelle, A.-L. Abraham, M. Mariadassou, E. Maguin, A.-J. Waligora-Dupriet, B. Pot, I. Wolowczuk and C. Grangette, C. (2016). Beneficial metabolic effects of selected probiotics on diet-induced obesity and insulin resistance in mice are associated with improvement of dysbiotic gut microbiota. Environ Microbiol. doi:10.1111/1462-2920.13181
  • C. Metzger, P. Luijckx, G. Bento, M. Mariadassou and D. Ebert (2016). The Red Queen lives: Epistasis between linked resistance loci. Evolution, 70(2):480–487. doi:10.1111/evo.12854
  • A. Goelzer, J. Muntel, V. Chubukov, M. Jules, E. Prestel, R. Nölker, M. Mariadassou, S. Aymerich, M. Hecker, P. Noirot and D. Becher (2015). Quantitative prediction of genome-wide resource allocation in bacteria. Metabolic Engineering, 32:232-243. doi:10.1016/j.ymben.2015.10.003
  • V. Brault and M. Mariadassou (2015). Co-clustering through Latent Bloc Model: a Review. Journal de la Société Française de Statistique, 156(3):120-139. Lien
  • A. Roulin, M. Mariadassou, M. Hall, J-C. Walser, C. Haag and D. Ebert (2015). High genetic variation in resting stage production in a metapopulation: Is there evidence for local adaptation?. Evolution, 69(10):2747-2756. DOI: 10.1111/evo.12770
  • M. Mariadassou, S. Pichon and D. Ebert (2015). Microbial ecosystems are dominated by specialist taxa, Ecology Letters, 18(9):974-982. DOI: 10.1111/ele.12478.
    Vignette [pdf, Rnw] and R code used to compute specificity index and perform the permutation test.
  • V. Loux, M. Mariadassou, S. Almeida, H. Chiapello, A. Hammani, J. Buratti, A. Gendrault, V. Barbe, J.-M. Aury, S.-M. Deutsch, S. Parayre, M.-N. Madec, V. Chuat, G. Jan, P. Peterlongo, V. Avezedo, Y. Le Loir and H. Falentin (2015). Mutations and genomic islands explain the strain dependancy of sugar utilization among  21 strains of Propionibacterium freudenreichii, BMC Genomics, 16:296. DOI: 10.1186/s12864-015-1467-7
  • Mariadassou, M. and Matias C. (2015). Convergence of the groups posterior distribution in latent or stochastic block models. Bernoulli, 21(1):537-573 DOI:10.3150/13-BEJ579
  • M. Mariadassou and F.-X. Pellay (2014). Identification of amino acids in mitochondrially encoded proteins that correlate with lifespan. Exp. Gerontology, 56:53-58. dx.doi.org/10.1016/j.exger.2014.03.009
  • C. Santos-Rocha, A. Cristina Gomes-Santos, T. Garcias Moreira, M. de Azevedo, T. D. Luerce, M. Mariadassou, A. P. Longaray Delamare, P. Langella, E. Maguin, V. Azevedo, A. M. Caetano Faria, A. Miyoshi, M. van de Guchte (2014). Local and systemic immune mechanism underlying the anti-colitis effects of the dairy bacterium Lactobacillus delbrueckii. PLoS One, 9(1): e85923. doi:10.1371/journal.pone.0085923
  • Gibrat, J., Mariadassou, M., Boudinot, P. and Delmas, B. (2013). Analyses of the radiation of birnaviruses from diverse host phyla and of their evolutionary affinities with other double-stranded rna and positive strand rna viruses using robust structure-based multiple sequence alignments and advanced phylogenetic methods. BMC Evol Biol. 13: 154. Link
  • Mariadassou, M., Bar-Hen, A. and Kishino, H. (2012). Taxon influence index: assessing taxon-induced incongruities in phylogenetic inference. Syst. Biol., 61:(2),337-345.
    Linkarticle data and R code.
  • Szczepankowska, A. K., Prestel, E., Mariadassou, M., Bardowski, J. K. and Bidnenko, E. (2011). Phylogenetic and complementation analysis of a single-stranded dna binding protein family from lactococcal phages indicates a non-bacterial origin. PLoS One, 6(11)e26942.Link.
  • M. Mariadassou, S. Robin, C. Vacher (2010). Uncovering Latent Structure in Valued Graphs: A Variational Approach. Annals of Applied Statistics, 4:2,715--742.Link and software mixnet.
  • M. Mariadassou, A. Bar-Hen (2009). Concentration inequality for evolutionary trees.Journal of Multivariate Analysis, 100, 2055--2064(Link)
  • A. Bar-Hen, M. Mariadassou, M.-A. Poursat, Ph. Vandenkoornhuyse (2008). Influence Function for Robust Phylogenetic Reconstructions. Molecular Biology and Evolution, 25:5, 869--873 (Link)

Oral Presentations

International Conferences

National Workshops

Lab Seminars