Garnier Jean Home Page

Background studies:

MSc in Agronomy, Physical Chemistry, Institut National Agronomique, Paris, 1949-1952. -Diploma of Pasteur Institute, Paris, Immunology and Microbiology, 1954. -Ph D, Doctor es-Sciences, Physics, University of Paris, Sorbonne, 1962.

Post-Doctoral Studies

Massachusetts Institute of Technology, Cambridge, Mass. USA, Department of Biology, Prof. D.F. Waugh, 1958-1959.

Research Positions

  • Research position at the Institut National de la Recherche Agronomique (INRA) from 1951 to 1996. From 1972 to 1986 my laboratory was located at the University of Paris-Sud, Orsay. Present position: Honorary Director of Research, Chargé de mission at the Mathématique Informatique et Génome (MIG) Laboratory, Jouy en Josas, France and part time at the Mathematical, Statistical Computing Laboratory, CIT, NIH, Bethesda, USA.
  • Editor in chief, Biophysical Reviews, Springer, a journal sponsored by IUPAB.

Academic Rewards

Order of Honors in Agronomy (Mérite Agricole), Officer, 1978.

Order of Honors in Education (Palmes Académiques), Knight, 1975.

Laureate of the Ministry of Agriculture, USA, 1961-1966 for researches conducted under Public Law 480.

Fogarty Scholar-in-Residence, NIH, Bethesda, USA, 1993 - 1996.

Areas of Research

  • Structure of Casein micelles in milk, 22 references
  • Mechanism of enzyme action, 23 references
  • Mechanism of protein folding, 15 references
  • Hormone receptors and membrane properties, 25 references including the first cloning of a gonadotropin receptor in 1989.
  • Secondary structure prediction in proteins, 20 references, including the GOR method for predicting secondary structures with a computer (1978), a pioneering work in Bioinformatics.
  • Protein structure prediction and numerical simulations, 26 references including a book: “Introduction to Proteins and Protein Engineering”. B. Robson and J. Garnier, 720 pages. Elsevier, 1986 and 1988. Amsterdam (commissioned work).
  • Biological databases and structural genomics projects.



References since 1996

  • R. Salesse J. Garnier. Glycoprotein hormone receptors : new molecular supports for old biological functions. Biomembranes, (1996), vol. 2,B A.G. LEE Ed. JAI Press Inc.,387-462.
  • V. di Francesco, J. Garnier, P.J. Munson, Improving protein secondary structure prediction with aligned homologous sequences. Protein Science, (1996), 5, 106-113
  • J. Garnier, J.F. Gibrat, B. Robson, GOR method for predicting protein secondary structure from amino acid sequence, Methods in Enzymology, R. Doolittle Ed., Acad. Press, (1996), vol. 266, chap. 32, 540-553.
  • V. di Francesco, P. Mcqueen, J. Garnier, P.J. Munson. Incorporating global information into secondary structure prediction with hidden Markov models of protein folds. In Proc. 4th Int. Conf. Intel. Sys. Mol. Biol. Halkidiki, Grece, (1997), 100-103.
  • V. di Francesco, J. Garnier P. Munson. Protein topology recognition from secondary structure sequences-Application of the hidden Markov models to the alpha class proteins. J. Mol. Biol. (1997) , 267, 446-463
  • V. di Francesco, V. Geetha, J. Garnier, P. Munson. Fold recognition using predicted secondary structure sequences and hidden Markov models of protein folds. Proteins:Struct. Funct. Genet. (1997), Sup. 1, 123-128.
  • V. di Francesco, P. Munson, J. Garnier. FORESST: fold recognition from secondary structure predictions of proteins. Bioinformatics, (1999), 15, 131-140.
  • V. Geetha, V. di Francesco, , J. Garnier, P. Munson. Comparing protein sequence-based and predicted secondary structure-based methods for identification of remote homologues. Protein Engineering, (1999), 12, 527-534.
  • A. Kloczkowski, K-L. Ting, R.L. Jernigan and J. Garnier. Protein Secondary Structure Prediction Based on the GOR Algorithm Incorporating Multiple Sequence Alignment Information. Polymer (2002), 43, 441-449.
  • A. Kloczkowski, K-L. Ting, R.L. Jernigan and J. Garnier. Combining the GOR V Algorithm With Evolutionary Information for Protein Secondary Structure Prediction from Amino Aid sequence. Proteins: Structure, Function, and Genetics, (2002) 49, 154-166
  • B. Robson and J. Garnier. The future of highly personalized health care. Stud. Health Technol. Inform. (2002) 80:163-174.
  • J. Garnier and H.J.C. Berendsen. International Unions concerned about biodata. Nature, (2002) 419, 777.
  • M. Hoebeke, H. Chiapello, J-F. Gibrat, Ph. Bessieres, J. Garnier. Annotation and Databases: Status and Prospects in Database annotation, A. Lesk Ed., John Wiley & Sons, London. (2004).
  • T., Z. Sen, R.L. Jernigan, J. Garnier, A. Kloczkowski. GOR V server for protein secondary structure prediction. Bioinformatics, Application Note. (2005) 21, 2787-2788.
  • V. Sam, C-H Tai, J. Garnier, J-F Gibrat, Bk Lee and P J Munson. ROC and confusion analysis of structure comparison methods identify the main causes of divergence from manual protein classification BMC Bioinformatics (2006), 7:206, 20 p.
  • J. Garnier. Protein structure evolution, a challenge. IUPAB News. (2006), 52:2-6
  • V. Sam, C-H Tai, J. Garnier, J-F Gibrat, Bk Lee and P J Munson. Towards an automatic classification of protein structural domains based on structural similarity. BMC Bioinformatics (2008) 9:74, 18p.
  • C-H Tai, V Sam, J-F Gibrat, J. Garnier, P.J. Munson and BK Lee. Protein domain assignment from the recurrence of locally similar structures. PROTEINS: Structure, Function, and Bioinformatics (2011); 79:853-866.
  • F. Samson, R. Shrager, C-H. Tai, V. Sam, B-K. Lee, P.J. Munson, J-F. Gibrat and J. Garnier. DOMIRE: a web server for identifying structural domains and their neighbors in proteins. BIOINFORMATICS (2012);28:1040-1041.